![]() ![]() The king is the most important piece in a game of chess. These pieces have different names in different languages, but their roles and relative values remain consistent. The names of the chess pieces are inspired by the royal court and foot soldiers of medieval times. Each player has eight pieces on their first rank (the row closest to them) and eight pawns on their second rank. The chess board is made up of 64 squares, with alternating light squares and dark squares. ![]() The Typical Chess Set and BoardĪ standard chess set consists of 32 unique chess pieces: 16 white pieces and 16 black pieces. This guide will provide a detailed explanation of the different types of chess pieces, their moves, and special rules.īy the end, you will be equipped to teach your child about this captivating game. The objective is simple: to checkmate your opponent’s king. So, grab your chess set, and let’s get started!Ĭhess is a strategic board game enjoyed by millions of people worldwide. In this guide, I’ll walk you through the ins and outs of the game, from chess piece names to their moves and everything in between. Whether it’s a rainy day indoors or a quiet evening together, chess is a fantastic way to bond with your children while teaching them valuable life skills. It’s so fulfilling to see my little ones develop their strategic thinking and decision-making skills, and it never ceases to amaze me how quickly they learn to challenge me on the chess board. As a mum who loves playing chess with my kids, I can’t wait to share my passion for this age-old game with you.
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![]() Likewise, C. audax and C. lateralis are very similar in morphology, with limited diagnostic traits that differentiate both species ( Smith & Miller, 1986). This led to C. garmani being considered synonymous with C. lateralis until Smith & Miller (1986) resurrected it as a valid taxon. Characodon lateralis and C. garmani were described in 18 respectively, based on a brief description of morphological characters with limited diagnostic value. Taxonomy and classification of the genus had been historically uncertain and unstable, mainly due to limitations in the original descriptions. Previous studies found that the distribution areas of C. audax and C. lateralis are separated by the waterfall known as El Salto, locating C. audax north (above) of waterfall and C. lateralis south (below) of it ( Domínguez-Domínguez et al., 2010). ![]() Characodon lateralis was described from an uncertain locality in “Central America”, but this is likely to be an error considering that no specific locality was given for the type material. ![]() The genus has a disjunct distribution pattern: C. garmani occurs in the northeast of Mexico within the Nazas River basin ( Miller, Minckley & Norris, 2005), whereas C. audax and C. lateralis occur in the northwest of Mexico at the headwaters of the Mezquital River basin ( Domínguez-Domínguez et al., 2010). The genus is represented by three recognized species: Characodon lateralis ( Günther, 1866), C. garmani ( Jordan & Evermann, 1898) and C. audax ( Smith & Miller, 1986), all of which are restricted to isolated springs and streams in the northern arid highlands of the states of Durango and Coahuila, Northern Mexico ( Domínguez-Domínguez, Doadrio & Perez-Ponce De Leon, 2006). The genus Characodon is the earliest diverging lineage of the Goodeinae subfamily, sharing a common ancestor with the rest of Goodeinae around 15.5 Mya ( Domínguez-Domínguez et al., 2010). Goodeids are notable for their unusual reproductive biology among fishes, typified by internal fertilization, viviparity and matrotrophy (the continuous extra-vitelline supply of nutrients from the parent to the progeny during gestation) ( Miller, Minckley & Norris, 2005 see details of these goodeid traits in ( Uribe et al., 2018)). ![]() The members of the subfamily Goodeinae are small-bodied freshwater fishes widespread throughout the Mexican highlands and adjacent areas, encompassing approximately 40 species. The possible processes identified as contributing to the formation of differentiated genetic groups are isolation, low population size, recurrent bottlenecks, and the strong sexual selection exhibited by the genus. Significant genetic structure was found within each haplogroup and suggests the existence of at least four Evolutionary Significant Units (ESUs) within the examined populations. The results with both markers show the presence of two highly differentiated haplogroups one distributed north and the other distributed south of the waterfall, with genetic distances of 1.7 and 13.1% with cytb and d-loop respectively, and divergence calculated to have occurred 1.41 Mya. We perform a phylogeographic study using the mitochondrial cytb gene and d-loop region to elucidate the evolutionary history of C. audax are classed as endangered, and have been the subject of taxonomic controversy since their description: previous studies have recognized a genetic differentiation in two groups separated by the El Salto waterfall, but morphological analyses contradict these genetic results. garmani, with the latter, considered extinct. Within this subfamily, the genus Characodon is the earliest diverging lineage of which three species have been described: C. Most of the species are restricted to small and isolated streams or springs. The subfamily Goodeinae is a group of fishes endemic to the Mexican highlands. Genetic differentiation in the genus Characodon: implications for conservation and taxonomy. Cite this article Beltrán-López RG, Pérez-Rodríguez R, Montañez-García OC, Artigas-Azas JM, Köck M, Mar-Silva AF, Domínguez-Domínguez O. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. Licence This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. 5 Haus des Meeres Aqua-Terra Zoo, Vienna, Austria DOI 10.7717/peerj.11492 Published Accepted Received Academic Editor Nicholas Jeffery Subject Areas Biogeography, Conservation Biology, Evolutionary Studies, Taxonomy, Freshwater Biology Keywords Goodeidae, Endemic, ESU, Evolutionary history, Taxonomy, Conservation Copyright © 2021 Beltrán-López et al. The AI medical chatbot can collect necessary information, such as medication name, dosage, and pharmacy details, and relay this information to the consulting doctor for review and approval. Patients can interact with AI medical chatbot to request prescription refills or submit new prescription requests. Kommunicate’s AI chatbots can send automated reminders to patients when it's time to refill their prescriptions or take medication, helping to improve medication adherence. Keep them informed, gain their trust with constant communication. Reduce no-shows for appointment bookings with reminders and notify patients to take medicines at prescribed hours. For instance, if a lab report shows abnormal cholesterol levels, the chatbot can suggest lifestyle changes or follow-up appointments with an available consultant Kommunicate’s healthcare AI chatbot can recommend appropriate actions or provide instructions based on the test results. They can also answer frequently asked questions related to specific lab tests. The AI chatbot can further assist in interpreting lab test reports, providing patients with explanations of various parameters, highlighting abnormal values, and offering general guidance. Additionally, the healthcare AI chatbot can collect and store patient information to track patient health histories and medication history, creating a more efficient record-keeping system. The AI chatbot can also help simplify the request process of new prescriptions or tests, allowing patients to request them quickly and conveniently. Patients can access their reports conveniently, review the results, and seek further guidance. Kommnuicate’s AI chatbot for healthcare can securely deliver lab test reports to patients through messaging platforms such as WhatsApp, Telegram, and Messenger or within a dedicated patient portal. ![]() Kommunicate’s AI Chatbot can help deliver prescriptions and lab test reports by streamlining the process, reducing human errors, and improving customer service. Real-time sharing and downloading of medication prescriptions and lab test reports by AI Chatbot for Healthcare on WhatsApp, Facebook, Instagram, Telegram, and more. 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Kommunicate’s AI-powered medical chatbot can check the availability of doctor’s schedules and book appointments accordingly, eliminating manual intervention. ![]() It also uses machine learning to match user questions to provided FAQs.ĪI Chatbot for Doctor Appointment BookingĪI Chatbot for doctors, clinics and hospitals to automate appointment scheduling, pre-screening, symptom checking, and providing relevant information.Ĭonversationally interact with your patients, gathering necessary information such as the patient's name, preferred date and time, and reason for the appointment. Kommunicate’s telemedicine AI Chatbot uses state-of-the-art Natural Language Understanding (NLU) to extract entities like location, time, disorder, drug or findings. ![]() The telemedicine AI chatbot ensures a seamless experience for all patients 24/7 round the clock. The telemedicine AI chatbot further helps collect payments for the consultation, eliminating any human involvement. Kommunicate’s telemedicine AI bot helps doctors to observe the patients in their environment to suggest best practices. Healthcare companies can provide real-time consultation to patients ensuring a faster diagnosis for quicker recovery. Kommunicate’s conversational AI solution enables healthcare providers to deliver virtual care services to their patients with its AI chatbots. Telemedicine AI bot for digital patient consultation, remote patient monitoring, and secured storage of personal data, all using a single platform made specifically for the healthcare industry. ![]()
![]() ![]() Virus infection expands a biased subset of T cells that bind tetrameric class I peptide complexes. Specificity and detection of insulin-reactive CD4 + T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse. The potential and challenges of exploiting the vast but dynamic neoepitope landscape for immunotherapy. Neoepitopes as cancer immunotherapy targets: key challenges and opportunities. More than one reason to rethink the use of peptides in vaccine design. A totally synthetic polyoxime malaria vaccine containing Plasmodium falciparum B cell and universal T cell epitopes elicits immune responses in volunteers of diverse HLA types. ![]() Major histocompatibility complex and T cell interactions of a universal T cell epitope from Plasmodium falciparum circumsporozoite protein. Immunomic analysis of the repertoire of T-cell specificities for influenza A virus in humans. Towards identification of immune and genetic correlates of severe influenza disease in indigenous Australians. Towards the knowledge-based design of universal influenza epitope ensemble vaccines. Generation of peptide-MHC class I complexes through UV-mediated ligand exchange. Enumeration and characterization of memory cells in the TH compartment. Phenotypic analysis of antigen-specific T lymphocytes. A large fraction of HLA class I ligands are proteasome-generated spliced peptides. Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens. Mass spectrometry profiling of HLA-associated peptidomes in mono-allelic cells enables more accurate epitope prediction. Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry. Defining the HLA class I-associated viral antigen repertoire from HIV-1-infected human cells. Mass spectrometry of human leukocyte antigen class I peptidomes reveals strong effects of protein abundance and turnover on antigen presentation. Elife 4, e07661 (2015).īassani-Sternberg, M., Pletscher-Frankild, S., Jensen, L. An open-source computational and data resource to analyze digital maps of immunopeptidomes. A comprehensive analysis of peptides presented by HLA-A1. Revisiting the arthritogenic peptide theory: quantitative not qualitative changes in the peptide repertoire of HLA-B27 allotypes. Expanding the detectable HLA peptide repertoire using electron-transfer/higher-energy collision dissociation (EThcD). Sampling from the proteome to the human leukocyte antigen-DR (HLA-DR) ligandome proceeds via high specificity. Early kinetics of the HLA class I-associated peptidome of MVA.HIVconsv-infected cells. A systems approach to understand antigen presentation and the immune response. With this protocol, several thousand peptides can be identified from a wide variety of cell types, including cancerous and infected cells and those from tissues, with a turnaround time of 2–3 d.ĭudek, N. This peptide cargo is then extracted and separated into fractions by HPLC, and the peptides in these fractions are identified using nUPLC–MS/MS. The peptides dissociate from the class I human leukocyte antigens (HLAs) upon acid denaturation. The protocol starts with the immunoaffinity capture of naturally processed MHC-peptide complexes. ![]() Here, we describe a robust protocol for the identification of MHC-bound peptides from cell lines and tissues, using nano-ultra-performance liquid chromatography coupled to high-resolution mass spectrometry (nUPLC–MS/MS) and recent improvements in methods for isolation and characterization of these peptides. Methods to identify these peptide antigens are critical to the development of new vaccines, for which the goal is the generation of effective adaptive immune responses and long-lasting immune memory. This critical arm of the adaptive immune system facilitates the eradication of pathogen-infected and cancerous cells, as well as the production of antibodies. Peptide antigens bound to molecules encoded by the major histocompatibility complex (MHC) and presented on the cell surface form the targets of T lymphocytes. ![]() But I do not worry about users figuring out the flag. That should be an acceptable alternative. As you can see here there are some devs that prefer titles for achievements they've created to remain unflagged for aesthetic or spoiler reasons.īecause of that we want to include a revision process to allow Devs to have room to object to such changes, and I'd prefer favoring the wishes of Devs who want their sets unflagged (so long as the missables are indicated in the standard place in the forum). There's been an ongoing discussion about if there needs to be a revision or not in the admin and staff channels. Also it should depend on the length of the game to beat if such label should be used or not or else you can just label any game with Save function as 'missable'. Using some Cryptic-Signs in Description is not good for casual players. In the end it should be easy to understanding for everyone who doesn't visits the Site daily but still collects Cheevos, sort of newcomer friendly, not confusing people. you get the idea so the regular Description doesn't have to be spammed with 'without dying' 'no damage' 'missables'. I agree with JAM and Jamiras, it should only be for long games (mostly RPGs) and labeled as instead of some Code not many understand what that means or simply expand the Cheevo Description by a additional line only for important information like missable achievement or difficulty etc. However, most people are lazy to make backups of their Saves nowadays so labeling Cheevos as missable makes sense. Technically there is no such thing as missables in Retro Games due to lack of auto-saving feature, missables are common among Modern Games with constant auto-saving and no way to creating backups of Save Files. If there's a need maybe a Discord channel can be made. Improvement ideas, questions, comments or talk collaboration should happen in this topic. Creating lists of missable achievements or creating guides is an excellent way for non-dev users to contribute to the community. To the top post of every current RPG-type set where missables are not identified to help players know when missables have been identified or flagged.ĥ.Keeping Track: To keep track of everything and collaborate I've create an open spreadsheet listing all RPGs of any kind and any other set that has missables flagged. If you've created a guide let the admin know via RAdmin so we can link the guide in the forum. Other guides could be more or less detailed. To prevent showing spoilers a link to a missables guide (if made) will also be posted in the top post of the forum topic,Īny user or dev can create a missable guide or a general achievement set guide (use RAGuides) and a revision does not need to be approved for a guide to be posted. Will be be added to the top post of the official forum topic.Į. See this forum topic for Legend of Zelda, The: Link's Awakening DX (Game Boy Color) as an example. If approved the flags will be added to the titles and in the top post of the official forum topic of that game, it will say, Any Dev can take this list and propose adding the flags to a set as a revision.Ĭ. Any user can either post a list of missables in the forum topic for a game or make a request there for missables to be flagged.ī. Current sets: Getting current missables identified and flagged will take a collaborative effort from the community.Ī. ![]() You can flag missables to any type of set, but the focus here is RPGs of any kind.ģ. Will be be added to the top post of the official forum topic. Unlisted/ Listed here (In forum post/guide/etc.) If there are missables for an RPG and you don't flag them, (devs) New Sets: Flagging missables in new sets is up to your preference. The flag can be used on any kind of set but RPGs are the main focus.Ģ. should not be used to flag anything else, to avoid confusion. (devs) The Flag: The flag is to be used as a consistency standard for missables, placed at the end of achievement titles. Because of the potential frustration it can cause most players prefer that missable achievements for RPGs are flagged. ![]() This scenario is reminiscent of a child on a seesaw, pushing down on one end with all their might. They stand tall, like a lever arm, with the wind exerting its force high up at the turbine’s shaft. Picture these turbines as towering giants, their heads piercing the sky, their bodies plunging into the depths of the sea. Three of the common types of floating wind turbine platforms. ![]() Why this insatiable demand for steel? The answer lies in the realm of physics. This implies that managing a floating wind project’s capital expenditure will necessitate large and cost-efficient fabrication capacities, likely situated far from the installation sites in Europe or the US. The steel requirement for each floater is estimated to be twice that of monopile foundations for bottom-fixed wind farms. However, the future seems to favor steel, with the majority of the floating offshore wind farms in the coming years expected to be steel-based. Some are opting for concrete over steel, as exemplified by the Hywind Tampen project. The industry is locked in a race against time, innovating and experimenting with various floater designs. To realize such a venture, we would need an armada of no less than 67 of these gargantuan foundations, or a smaller number of massive floaters would have to support much larger turbines.Īlso Read: Equinor Begins Power Production at Hywind Tampen, Norway’s First Floating Offshore Wind Farm Envision a 1 GW floating offshore wind farm, energized by the largest commercially available 15MW turbines. ![]() But this is merely the introductory chapter. Their combined might? An impressive 80 MW. The Hywind Scotland and Kincardine pilot projects, trailblazers in this new frontier, each command an army of five floaters. Experts believe that these floating leviathans of the sea represent the future of offshore wind energy, promising a new era of sustainable power generation that can tap into the vast wind resources of the deep oceans. This is where floating wind farms come into play.įloaters can be located in areas of high wind potential, in thousands of feet of water (for comparison Perdido, Spanish for lost, is the deepest floating oil platform in the world and is capable of anchoring in 8000 feet of water), reducing visual impact and potential conflicts with other marine uses. The cost and complexity of installing fixed foundations increase significantly with water depth, making them less feasible for deepwater locations. However, as we venture further from the shore, into deeper waters where the winds are stronger and more consistent, the limitations of bottom-fixed turbines become apparent. This approach has been favored due to its stability and the relative ease of installation in shallow to medium-depth waters, and relatively short transmission line distances to shore. These bottom-fixed turbines stand high as sentinels in the ocean, harnessing the power of the wind. Today the vast majority of offshore wind turbines are built on foundations resting firmly upon the seafloor. This will require a scale of ambition larger than the towers themselves. However, the construction of such stability presents significant challenges, including the mobilization of vast manpower, the procurement of substantial materials, and the deployment of an immense quantity of steel. Crafted to withstand the harshest marine conditions, these floaters promise to deliver unwavering, zero-emission energy. Engineers envision these to be towering structures, reaching hundreds of meters into the sky, perched atop colossal floating platforms, anchored in the profound abyss of the sea, to seabeds thousands of feet beneath. These are not the mythical leviathans of ancient seafarer’s tales, but the trailblazers of a sustainable future – floating wind turbines. By John Konrad (gCaptain) Far offshore, in the limitless expanse of the ocean, where the wind conducts the rhythmic ballet of the waves and the horizon stretches into the infinite, a new lineage of titans is being conceived. ![]() He was preceded in death by his parents and two brothers, John and Dennis.įamily prefers memorials to the ALS Association. Martin of Bemidji, Tracey of Buffalo, WY and Linc (Debra) of Sheridan, WY two brothers, Thomas (Shirley) of Aitkin and Michael (Connie) Of Pueblo, CO three grandchildren sisters-in-law, Judy Gravelle of Remer, Dixie (John) Stirwaldt of Perham and Connie (Dan) Walsh of Butte, MT and many nieces and nephews. He is survived by his wife, Lola of Bemidji and Yuma, AZ and three children, Dawn Peterson of Bemidji, Vicki Gravelle of Coon Rapids and Mark (Michelle) of Remer three stepchildren, Saunda St. He served as president of the Rio Colorado Homeowners Assoc. After retirement, Dick and Lola spent their winters in Yuma, AZ where he was active in running their homeowners association. Dick loved the outdoors as well as fishing and gardening and enjoyed sharing his garden products and catch of fish with friends and family. View Charles U Schwartz results in Denver, CO including current phone number, address, relatives, background check report, and property record with Whitepages. Back in print as a University Press of Colorado edition, this abundantly. They later divorced and then married Lola Weaver in 1991 in Bemidji. Ecology and Management of the North American Moose : Schwartz, Charles C. In 1965 he married Wanda Jerzak in Wilno, MN. He moved to Bemidji in 1970 and worked there until his retirement in 2008. Lukes Hospital School of Anesthesia in Aberdeen, SD. Army and was stationed at El Paso, TX and South Vietnam. ![]() He graduated from nursing school in Sioux Falls, SD in 1965. He was raised and went to school in Aitkin, MN. ![]() Richard was born Novemin Brainerd, MN to Clifford and Margaret (Janzen) Gravelle. Gravelle, 72, of Bemidji, MN died Saturday, Januat Neilson Place, Bemidji.Ī Celebration of Life will be held in the spring with inurnment in the Hines Cemetery. This means that if you want to get first dibs into buying the much coveted Taylor Swift tickets, you’d need to be a UOB cardholder. ![]() Here’s the spill - UOB credit and debit cardholders will have the privilege of obtaining Taylor Swift’s tour tickets a full 48 hours before the general public from 5 July 2023 onwards. What many of you might be most interested is – how do I get my hands on tickets for Taylor Swift concert? ![]() If you're wondering how much attending the Taylor Swift concert in Singapore will cost you, here are the ticket prices: With all the excitement, it's no surprise that The Eras Tour could be the first billion-dollar tour ! Source: Singapore Sports Hub The site does not review or include all companies or all available products.Good news for Swifties in Singapore – Taylor Swift will be coming to Singapore for The Eras Tour on 2,3,4 & 7,8,9 March 2024. ValueChampion is not to be construed as in any way engaging or being involved in the distribution or sale of any financial product or assuming any risk or undertaking any liability in respect of any financial product. We strive to have the most current information on our site, but consumers should inquire with the relevant financial institution if they have any questions, including eligibility to buy financial products. Our partners cannot pay us to guarantee favorable reviews of their products or services However, this does not affect our recommendations or advice, which are grounded in thousands of hours of research. This compensation may impact how and where offers appear on this site (including, for example, the order in which they appear). Some of the offers that appear on this website are from companies which ValueChampion receives compensation. However, the guides and tools we create are based on objective and independent analysis so that they can help everyone make financial decisions with confidence. Our site may not feature every company or financial product available on the market. Use our quick and easy-to-read guide below to learn how you can redeem card rewards.Īdvertiser Disclosure: ValueChampion is a free source of information and tools for consumers. ![]() How Does Maybank Friends & Family Credit Card’s Rewards Program Work? Few options on the market can match this card's combination of high rates and low minimum requirements, lack of merchant restrictions, and customized cashback categories based on your preferences. Nonetheless, Maybank F&F Card stands out for its incredible value to both lower and average spenders who have local or regional budgets and want to earn on everyday spend. 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